Ravagalimab

Names

[ CAS No. ]:
2050816-56-1

[ Name ]:
Ravagalimab

Biological Activity

[Description]:

Ravagalimab (ABBV-323) is a CD40 antagonist (EC50: 3.7 nM). Ravagalimab can be used for research of Crohn's disease[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[Target]

CD40:3.7 nM (EC50)

[In Vitro]

Ravagalimab (0-100 nM，2 天) 抑制原代人 B 细胞上的 CD86 上调，EC50 为 0.6 nM[2]。

[References]

[1]. Argiriadi MA, et al. CD40/anti-CD40 antibody complexes which illustrate agonist and antagonist structural switches. BMC Mol Cell Biol. 2019 Aug 5;20(1):29.

[2]. Yu X, et al. Isotype Switching Converts Anti-CD40 Antagonism to Agonism to Elicit Potent Antitumor Activity. Cancer Cell. 2020 Jun 8;37(6):850-866.e7.

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds

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