K67

Names

[ CAS No. ]:
2046250-48-8

[ Name ]:
K67

[Synonym ]:
N,N'-[2-(2-Oxopropyl)naphthalene-1,4-Diyl]bis(4-Ethoxybenzenesulfonamide)
2-Acetonyl-1,4-bis[(4-ethoxybenzensulfonyl)amino]naphthalene
N,N'-(2-(2-Oxopropyl)naphthalene-1,4-diyl)bis(4-ethoxybenzenesulfonamide)
Benzenesulfonamide, N,N'-[2-(2-oxopropyl)-1,4-naphthalenediyl]bis[4-ethoxy-
N,N'-[2-(2-Oxopropyl)-1,4-naphthalenediyl]bis(4-ethoxybenzenesulfonamide)
K67
N-[2-Acetonyl-4-(4-ethoxybenzenesulfonylamino)naphthalene-1-yl]-4-ethoxybenzenesulfonamide

Biological Activity

[Description]:

K67 is a specific inhibitor of the interaction between S349-phosphorylated p62 and Keap1, exhibts no inhibitory effect on the interaction of full-length Keap1 with Nrf2-ETGE or full-length Nrf2; has specific inhibitory effect on the Nrf2 target genes, dramatically suppresses the proliferations of Huh1 cells and of Huh7 cells expressing phospho-mimetic p62.

[References]

References 1. Saito T, et al. Nat Commun. 2016 Jun 27;7:12030. View Related Products by Target Keap1-Nrf2

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
752.2±70.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₉H₃₀N₂O₇S₂

[ Molecular Weight ]:
582.688

[ Flash Point ]:
408.7±35.7 °C

[ Exact Mass ]:
582.149414

[ LogP ]:
5.09

[ Vapour Pressure ]:
0.0±2.5 mmHg at 25°C

[ Index of Refraction ]:
1.640