LY377604

Names

[ CAS No. ]:
204592-94-9

[ Name ]:
LY377604

[Synonym ]:
unii-occ6tb3p6k
LY377604

Biological Activity

[Description]:

LY377604 is a human β3-adrenergic receptor agonist with an EC50 of 2.4 nM and also a β1- and β2-adrenergic receptor antagonist.

[Related Catalog]:

Research Areas >> Endocrinology

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

Research Areas >> Metabolic Disease

[Target]

EC50: 2.4 nM (human β3-adrenergic receptor)[1] β1-adrenergic receptor, β2-adrenergic receptor[1]

[In Vitro]

LY377604 is a human β3-adrenergic receptor agonist with an EC50 of 2.4 nM and also a β1- and β2-adrenergic receptor antagonist. LY377604 causes a maximal increase in cyclic adenosine monophosphate (cAMP) levels, but does not stimulate cAMP accumulation in CHO cells transfected with either the human β1 adrenergic receptor or the human β2 adrenergic receptor[1].

[In Vivo]

Administration of LY377604 to male Long-Evans rats fed a caloric dense diet results in stimulation of lipid utilization. This is observed as a decrease in respiratory quotient and persists for about 4 h before returning to that measured from vehicle-treated rats[1].

[References]

[1]. Jesudason CD, et al. Combination of a Beta adrenoceptor modulator and a norepinephrine-serotonin uptake inhibitor for the treatment of obesity. ACS Med Chem Lett. 2011 May 23;2(8):583-6.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₁H₃₂N₄O₄

[ Molecular Weight ]:
524.61000

[ Exact Mass ]:
524.24200

[ PSA ]:
123.48000

[ LogP ]:
6.23300

Related Compounds

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