L-Lysine-15N dihydrochloride

Names

[ CAS No. ]:
204451-50-3

[ Name ]:
L-Lysine-15N dihydrochloride

[Synonym ]:
L-Lysine-2-15N dihydrochloride

Biological Activity

[Description]:

L-Lysine-15N (dihydrochloride) is a 15N-labeled Deruxtecan. Deruxtecan is an ADC drug-linker conjugate composed of a derivative of DX-8951 (DXd) and amaleimide-GGFG peptide linker, used for synthesizing DS-8201 and U3-1402.

[Related Catalog]:

Research Areas >> Cancer

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[75].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-239.

[2]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-239.

Chemical & Physical Properties

[ Melting Point ]:
200-206ºC (dec.)(lit.)

[ Molecular Formula ]:
C6H16Cl2N15NO2

[ Molecular Weight ]:
220.10

[ Exact Mass ]:
219.05600

[ PSA ]:
89.34000

[ LogP ]:
2.53190

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
NONH for all modes of transport

Related Compounds