SU5416
Names
[ CAS No. ]:
204005-46-9
[ Name ]:
SU5416
[Synonym ]:
1,3-Dihydro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-2H-indol-2-one
semaxanib
(3Z)-3-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one
2H-Indol-2-one, 3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-, (3Z)-
SU 5416
SU5416
Biological Activity
[Description]:
[Related Catalog]:
[Target]
Flk-1:1.23 μM (IC50)
[In Vitro]
[In Vivo]
[Cell Assay]
[Animal admin]
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
481.4±45.0 °C at 760 mmHg
[ Molecular Formula ]:
C15H14N2O
[ Molecular Weight ]:
238.285
[ Flash Point ]:
244.9±28.7 °C
[ Exact Mass ]:
238.110611
[ PSA ]:
44.89000
[ LogP ]:
2.87
[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C
[ Index of Refraction ]:
1.684
[ Storage condition ]:
-20°C
MSDS
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
26-36
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ HS Code ]:
2933990090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933990090
[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
Am. J. Respir. Crit. Care Med. 184(10) , 1171-82, (2011)
The complex pathologies associated with severe pulmonary arterial hypertension (PAH) in humans have been a challenge to reproduce in mice due to the subtle phenotype displayed to PAH stimuli.Here we a...
Neurovascular development in the embryonic zebrafish hindbrain.Dev. Biol. 357(1) , 134-51, (2011)
The brain is made of billions of highly metabolically active neurons whose activities provide the seat for cognitive, affective, sensory and motor functions. The cerebral vasculature meets the brain's...
SU5416, a VEGF receptor inhibitor and ligand of the AHR, represents a new alternative for immunomodulation.PLoS ONE 7(9) , e44547, (2012)
The experimental compound SU5416 went as far as Phase III clinical trials as an anticancer agent, putatively because of its activity as a VEGFR-2 inhibitor, but showed poor results. Here, we show that...