(±)-Coclaurine

Names

[ CAS No. ]:
2033-08-1

[ Name ]:
(±)-Coclaurine

[Synonym ]:
1-(4-hydroxy-benzyl)-6-methoxy-1,2,3,4-tetrahydro-isoquinolin-7-ol
D,L-coclaurine
dl-coclaurine
(R,S)-coclaurine
(+/-)-coclaurine
1-(4-Hydroxy-benzyl)-6-methoxy-1,2,3,4-tetrahydro-isoquinolin-7-ol
(+/-)-Coclaurine

Biological Activity

[Description]:

(±)-Coclaurine is a natural product that can be found in Roemeria refracta. (±)-Coclaurine exhibits antioxidative activity and cardiovascular effects[1][2][3].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Others >> Others

[In Vitro]

(±)-Coclaurine (1 μM-1 mM) 以浓度依赖性方式松弛 KCl 诱导的主动脉环收缩[3]。

[References]

[1]. Gözler B, et, al. Epimeric Isopavine N-Oxides from Roemeria refracta. Phytotherapy Research. Helvetica. 1992 Feb 5; 75(1): 260-268.

[2]. Cassels BK, et, al. Structure-antioxidative activity relationships in benzylisoquinoline alkaloids. Pharmacol Res. 1995 Feb;31(2):103-7.  

[3]. Morales MA, et, al. Cardiovascular effects of plant secondary metabolites norarmepavine, coclaurine and norcoclaurine. Phytotherapy Research. 1998 Mar; 12(2): 103-109.

Chemical & Physical Properties

[ Molecular Formula ]:
C17H19NO3

[ Molecular Weight ]:
285.33800

[ Exact Mass ]:
285.13600

[ PSA ]:
61.72000

[ LogP ]:
2.86470

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.