Paeonoside

Names

[ CAS No. ]:
20309-70-0

[ Name ]:
Paeonoside

[Synonym ]:
2-Acetyl-5-methoxyphenyl beta-D-Glucopyranoside
(2-Acetyl-5-methoxy-phenyl)-β-D-glucopyranosid
2-Acetyl-5-methoxyphenyl β-D-glucopyranoside
Ethanone, 1-[2-(β-D-glucopyranosyloxy)-4-methoxyphenyl]-
paeonoside
(2-acetyl-5-methoxy-phenyl)-β-D-glucopyranoside
glucopaeonol
Resacetophenon-4-O-methyl-2-β-D-glucosid

Biological Activity

[Description]:

Paeonoside is a bioactive compound identified in P. suffruticosa that promotes wound healing and migration in osteoblast differentiation. Paeonoside has also been reported to have some antidiabetic activity and may prevent sepsis-induced lethality[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

Research Areas >> Metabolic Disease

[In Vitro]

Paeonoside (PASI) (0.1-100 μM, 24 h) has no cytotoxic effect on pro-osteoblasts of MC3T3-E1 cells[1]. Paeonoside (PASI) (1-30 μM, 24 h) can significantly restore wound areas and promote cell migration in a dose-dependent manner during the induction of preosteoblast of MC3T3-E1 cells differentiation using osteogenic supplement (OS) medium. In parallel, PASI promotes alkaline phosphatase (ALP) staining and its activity in a dose-dependent manner[1]. Western Blot Analysis[1] Cell Line: Pro-osteoblasts of MC3T3-E1 cells Concentration: 1-10 μM Incubation Time: 24 h Result: Increased the expression of BMP2 and Wnt3a, stimulated Smad1/5/8 phosphorylation, GSK3β phosphorylation and β-linked protein expression as well as upregulated RUNX2 expression.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
589.9±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₅H₂₀O₈

[ Molecular Weight ]:
328.315

[ Flash Point ]:
219.2±23.6 °C

[ Exact Mass ]:
328.115814

[ PSA ]:
125.68000

[ LogP ]:
-1.10

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.593

Related Compounds

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