TAM-16

Names

[ CAS No. ]:
2030241-59-7

[ Name ]:
TAM-16

[Synonym ]:
5-Hydroxy-2-(4-hydroxyphenyl)-N-methyl-4-(1-piperidinylmethyl)-1-benzofuran-3-carboxamide
3-Benzofurancarboxamide, 5-hydroxy-2-(4-hydroxyphenyl)-N-methyl-4-(1-piperidinylmethyl)-

Biological Activity

[Description]:

A benzofuran class inhibitor of M. tuberculosis Pks13 (Polyketide Synthase 13); show highly potent in vitro bactericidal activity against drug-susceptible and drug-resistant clinical isolates of M. tuberculosis (MICs: 0.06-0.25 uM); exhibits in vivo efficacy in multiple mouse models of TB infection, has excellent pharmacological and safety profiles.

[References]

References 1. Aggarwal A, et al. Cell. 2017 Jul 13;170(2):249-259.e25. View Related Products by Target Bacterial

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
609.9±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₂H₂₄N₂O₄

[ Molecular Weight ]:
380.437

[ Flash Point ]:
322.7±31.5 °C

[ Exact Mass ]:
380.173615

[ LogP ]:
1.94

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.652

Related Compounds

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