Tos-PEG5-CH2CO2H

Names

[ CAS No. ]:
2028284-73-1

[ Name ]:
Tos-PEG5-CH2CO2H

[Synonym ]:
MFCD30458013

Biological Activity

[Description]:

Tos-PEG4-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₂₆O₉S

[ Molecular Weight ]:
406.45

Related Compounds

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