Ralfinamide Mesylate

Names

[ CAS No. ]:
202825-45-4

[ Name ]:
Ralfinamide Mesylate

[Synonym ]:
RALFINAMIDE MESYLATE
(2S)-2-[[[4-[(2-FLUOROPHENYL)METHOXY]PHENYL]METHYL]AMINO]-PROPANAMIDE METHANESULFONATE
Ralfinamide mesylate
(S)-2-((4-((2-Fluorobenzyl)oxy)benzyl)amino)propanamide methanesulfonate

Biological Activity

[Description]:

Ralfinamide mesylate (FCE-26742A mesylate) is an orally available Na(+) channel blocker derived from α-aminoamide, with function of suppressing pain[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel

Research Areas >> Neurological Disease

[Target]

Na(+) channel

[References]

[1]. Zhang SH, et al. Ralfinamide administered orally before hindpaw neurectomy or postoperatively provided long-lasting suppression of spontaneous neuropathic pain-related behavior in the rat. Pain. 2008 Oct 15;139(2):293-305.

[2]. Liang X, et al. Effects of ralfinamide in models of nerve injury and chemotherapy-induced neuropathic pain. Eur J Pharmacol. 2018 Mar 15;823:27-34.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₂₃FN₂O₅S

[ Molecular Weight ]:
398.44900

[ Exact Mass ]:
398.13100

[ PSA ]:
127.10000

[ LogP ]:
4.04410

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301

[ Precautionary Statements ]:
P301 + P310

[ Hazard Codes ]:
T

[ RIDADR ]:
UN 2811 6.1 / PGIII

[ HS Code ]:
2924299090

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

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