(R)-Azasetron besylate

Names

[ CAS No. ]:
2025360-91-0

[ Name ]:
(R)-Azasetron besylate

Biological Activity

[Description]:

(R)-Azasetron besylate (SENS-401) is an orally active calcineurin inhibitor. (R)-Azasetron besylate reduces Cisplatin (HY-17394)-induced hearing loss and cochlear damage[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase

[References]

[1]. Petremann M, et al. SENS-401 Effectively Reduces Severe Acoustic Trauma-Induced Hearing Loss in Male Rats With Twice Daily Administration Delayed up to 96 hours. Otol Neurotol. 2019 Feb;40(2):254-263.

[2]. Petremann M, et al. Oral Administration of Clinical Stage Drug Candidate SENS-401 Effectively Reduces Cisplatin-induced Hearing Loss in Rats. Otol Neurotol. 2017 Oct;38(9):1355-1361.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₂₆ClN₃O₆S

[ Molecular Weight ]:
507.99

Related Compounds

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