Thalidomide-O-amido-C3-NH2

Names

[ CAS No. ]:
2022182-58-5

[ Name ]:
Thalidomide-O-amido-C3-NH2

Biological Activity

[Description]:

E3 Ligase Ligand-Linker Conjugates 52 TFA (Compound 10) incorporates a CRBN ligand for the E3 ubiquitin ligase, and a PROTAC linker. E3 Ligase Ligand-Linker Conjugates 52 TFA (Compound 10) is a PROTAC precursor[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate

[Target]

Cereblon

[References]

[1]. Lohbeck J, et al. Practical synthesis of a phthalimide-based Cereblon ligand to enable PROTAC development. Bioorg Med Chem Lett. 2016 Nov 1;26(21):5260-5262.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₂₁F₃N₄O₈

[ Molecular Weight ]:
502.40

Thalidomide-O-amido-C3-NH2

Names

Biological Activity

Chemical & Physical Properties

Related Compounds