HER2-IN-3
Names
[ CAS No. ]:
2011708-45-3
[ Name ]:
HER2-IN-3
Biological Activity
[Description]:
HER2-IN-3 is a type I HER2 inhibitor that has a similar profile to HER2-IN-2; shows superior activity to lapatinib in the 2YF/3wt + NRG cells and specificity for this cell line; remains sensitivity to HER2 mutations L755S (2YF-L755S/3wt), Y772_A775 dup (2YF-YVMA/3wt), and G776del_insVC (2YF-VC/3wt) cells.
[References]
References 1. Novotny CJ, et al. Nat Chem Biol. 2016 Nov;12(11):923-930. View Related Products by Target EGFR
Chemical & Physical Properties
[ Molecular Formula ]:
C20H16N6O2
[ Molecular Weight ]:
372.388