DPP-4/GPR119 modulator 2

Names

[ CAS No. ]:
2010927-65-6

[ Name ]:
DPP-4/GPR119 modulator 2

Biological Activity

[Description]:

DPP-4/GPR119 modulator 2 (Compound 20i) is a dipeptidyl peptidase IV (DPP-IV) inhibitor and GPR119 agonist with an IC50 of 0.22 µM for DPP-IV and an EC50 of 0.95 µM for GPR119. DPP-4/GPR119 modulator 2 can be used for diabetes research[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Dipeptidyl Peptidase

Signaling Pathways >> GPCR/G Protein >> GPR119

Research Areas >> Metabolic Disease

[Target]

IC50: 0.22 µM (DPP-IV)[1]. EC50: 0.95 µM (GPR119)[1]

[References]

[1]. Li G, et al. The optimization of xanthine derivatives leading to HBK001 hydrochloride as a potent dual ligand targeting DPP-IV and GPR119. Eur J Med Chem. 2020 Feb 15;188:112017.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₀H₄₀N₈O₃

[ Molecular Weight ]:
560.69

Related Compounds

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