4-Phenyl-1,3-thiazol-2-amine
Names
[ CAS No. ]:
2010-06-2
[ Name ]:
4-Phenyl-1,3-thiazol-2-amine
[Synonym ]:
MFCD00039680
2-Thiazolamine,4-phenyl
4-phenyl-2-aminothiazole
2-Amino-4-phenyl-1,3-thiazole
4-Phenyl-1,3-thiazol-2-amine
2-amino-4-phenylthiazol
4-Phenyl-2-thiazolylamine
Phenthiazamine
4-Phenylthiazol-2-amine
2-Amino-4-phenylthiazole
4-Phenyl-2-thiazolamine
4-phenyl-1,3-thiazole-2-amine
EINECS 217-926-8
4-Phenyl-thiazol-2-ylamine
Thiazole,2-amino-4-phenyl
2-Thiazolamine, 4-phenyl-
T5N CSJ BZ ER
4-phenyl-1,3-thiazol-2-ylamine
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
363.4±11.0 °C at 760 mmHg
[ Melting Point ]:
149-153 °C(lit.)
[ Molecular Formula ]:
C9H8N2S
[ Molecular Weight ]:
176.238
[ Flash Point ]:
173.6±19.3 °C
[ Exact Mass ]:
176.040817
[ PSA ]:
67.15000
[ LogP ]:
2.14
[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C
[ Index of Refraction ]:
1.660
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- XJ2878000
- CHEMICAL NAME :
- Thiazole, 2-amino-4-phenyl-
- CAS REGISTRY NUMBER :
- 2010-06-2
- LAST UPDATED :
- 199706
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C9-H8-N2-S
- MOLECULAR WEIGHT :
- 176.25
- WISWESSER LINE NOTATION :
- T5N CSJ BZ ER
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 140 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- EPXXDW European Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #0001727
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 320 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#00815
Safety Information
[ Symbol ]:
GHS05, GHS06
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H301-H315-H318-H335
[ Precautionary Statements ]:
P261-P280-P301 + P310-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves
[ Hazard Codes ]:
Xn: Harmful;Xi: Irritant;
[ Risk Phrases ]:
R22
[ Safety Phrases ]:
S26-S36/37/39
[ RIDADR ]:
UN 2811 6.1 / PGIII
[ WGK Germany ]:
3
[ RTECS ]:
XJ2878000
[ HS Code ]:
2934100090
Synthetic Route
Customs
[ HS Code ]: 2934100090
[ Summary ]:
2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%
Articles
J. Pharmacobiodyn. 3(2) , 85-93, (1980)
Phenthiazamine was developed by Sekizawa et al. as a centrally acting anesthetic for fish. Frog sympathetic ganglion was used as a model to elucidate the mechanism of its anesthetic action. The positi...