m-3M3FBS

Names

[ CAS No. ]:
200933-14-8

[ Name ]:
m-3M3FBS

[Synonym ]:
Tocris-1941
Phospholipase C Activator,m-3M3FBS
N-(3-Trifluoromethylphenyl)-2,4,6-trimethylbenzenesulfonamide
m-3M3FBS

Biological Activity

[Description]:

m-3M3FBS is a potent phospholipase C (PLC) activator. m-3M3FBS stimulates superoxide generation in human neutrophils, upregulates intracellular calcium concentration, and stimulates inositol phosphate generation in various cell lines. m-3M3FBS induces monocytic leukemia cell apoptosis[1][2][3].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase

[In Vitro]

m-3M3FBS (5-50 μM) stimulates the formation of inositol phosphates in U937 cells[1]. m-3M3FBS (50 μM; 24 hours) inhibits the growth of the leukemic cell lines U937 and THP-1, but not primary monocytes[3]. m-3M3FBS (50 μM; 24 hours) induces U937 cell apoptosis[3]. Cell Viability Assay[3] Cell Line: U937 and THP-1 cells Concentration: 50 μM Incubation Time: 24 hours Result: Inhibited the growth of the leukemic cell lines U937 and THP-1, but not primary monocytes. Cell Viability Assay[3] Cell Line: U937 cells Concentration: 50 μM Incubation Time: 24 hours Result: The apoptotic rate of m-3M3FBS-treated cells was 53.9%.

[References]

[1]. Bae YS, et al. Identification of a compound that directly stimulates phospholipase C activity. Mol Pharmacol. 2003;63(5):1043-1050.

[2]. Krjukova J, et al. Phospholipase C activator m-3M3FBS affects Ca2+ homeostasis independently of phospholipase C activation. Br J Pharmacol. 2004;143(1):3-7.

[3]. Lee YN, et al. The novel phospholipase C activator, m-3M3FBS, induces monocytic leukemia cell apoptosis. Cancer Lett. 2005;222(2):227-235.

Chemical & Physical Properties

[ Density]:
1.316g/cm3

[ Boiling Point ]:
420ºC at 760mmHg

[ Melting Point ]:
114-114.8ºC(lit.)

[ Molecular Formula ]:
C₁₆H₁₆F₃NO₂S

[ Molecular Weight ]:
343.36400

[ Flash Point ]:
207.8ºC

[ Exact Mass ]:
343.08500

[ PSA ]:
54.55000

[ LogP ]:
5.58520

[ Vapour Pressure ]:
2.92E-07mmHg at 25°C

[ Index of Refraction ]:
1.547

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2935009090

Customs

[ HS Code ]: 2935009090

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

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Related Compounds

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