C-11

Names

[ CAS No. ]:
2007965-97-9

[ Name ]:
C-11

Biological Activity

[Description]:

C-11 is a tubulysin-based antibody–drug conjugates (ADCs), displays cytotoxicity for carcinoma cell lines[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> Drug-Linker Conjugates for ADC

[In Vitro]

C-11 exhibits cytotoxicity for N87 cells and MDA-MB-361-DYT2 cells with IC50s of 1.11 nM and 0.9 nM, respectively[1].

[References]

[1]. Leverett CA, et al. Design, Synthesis, and Cytotoxic Evaluation of Novel Tubulysin Analogues as ADC Payloads. ACS Med Chem Lett. 2016 Aug 26;7(11):999-1004.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₈H₅₈N₆O₇S

[ Molecular Weight ]:
742.97

Related Compounds

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