Flumethasone 21-pivalate

Names

[ CAS No. ]:
2002-29-1

[ Name ]:
Flumethasone 21-pivalate

[Synonym ]:
MFCD00079287
Flumethasone pivalate
Flumethasone 21-Pivalate
[2-[(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] 2,2-dimethylpropanoate
EINECS 217-901-1

Biological Activity

[Description]:

Flumethasone pivalate is a glucocorticoid corticosteroid and a corticosteroid ester. Flumetasone pivalate has anti-inflammatory, antipruritic, and vasoconstrictive activities[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Mandour, A.A., et al. Review on analytical studies of some pharmaceutical compounds containing heterocyclic rings: brinzolamide, timolol maleate, flumethasone pivalate, and clioquinol. Futur J Pharm Sci 6, 52 (2020).

Chemical & Physical Properties

[ Density]:
1.27g/cm3

[ Boiling Point ]:
600.3ºC at 760mmHg

[ Molecular Formula ]:
C₂₇H₃₆F₂O₆

[ Molecular Weight ]:
494.56800

[ Flash Point ]:
316.8ºC

[ Exact Mass ]:
494.24800

[ PSA ]:
100.90000

[ LogP ]:
3.44070

[ Vapour Pressure ]:
6.51E-17mmHg at 25°C

[ Index of Refraction ]:
1.55

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU3832010

CHEMICAL NAME :: Pregna-1,4-diene-3,20-dione, 6-alpha,9-difluoro-11-beta,17,21-trihydroxy-16-alpha- methyl-, 21-pivalate

CAS REGISTRY NUMBER :: 2002-29-1

LAST UPDATED :: 199710

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C27-H36-F2-O6

MOLECULAR WEIGHT :: 494.63

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,705,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,705,1982

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H351

[ Precautionary Statements ]:
P280

[ Personal Protective Equipment ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R40

[ Safety Phrases ]:
S22-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
TU3832010

Precursor & DownStream

Precursor

DownStream

Articles

Lecithin based nanoemulsions: A comparative study of the influence of non-ionic surfactants and the cationic phytosphingosine on physicochemical behaviour and skin permeation.

Int. J. Pharm. 370(1-2) , 181-6, (2009)

Charged drug delivery systems are interesting candidates for the delivery of drugs through skin. In the present study, it was possible to create negatively and positively charged oil/water nanoemulsio...

[Darkness effect in photochemotherapy. I. Effect of 8-methoxypsoralen on the epidermal patch test in allergic contact eczema].

Dermatol. Monatsschr. 169(1) , 46-8, (1983)

[Double-blind comparison of a betamethasone dipropionate-iodochloroxyquinoline combination and a flumethasone pivalate-iodochloroxyquinoline combination in the therapy of steroid-sensitive dermatoses with superinfection].

G. Ital. Dermatol. Venereol. 121(1) , XI-XIV, (1986)