INH14

Names

[ CAS No. ]:
200134-22-1

[ Name ]:
INH14

Biological Activity

[Description]:

INH14 is a cell permeable inhibitor of IKKα/IKKβ, with IC50s of 8.97 and 3.59 μM, respectively. INH14 inhibits the IKKα/β-dependent TLR inflammatory response. INH14 also inhibits downstream of TAK1/TAB1 and NF-kB pathways. Anti-inflammatory and anti-cancer activity[1].

[Related Catalog]:

Signaling Pathways >> NF-κB >> IKK

Research Areas >> Cancer

Research Areas >> Inflammation/Immunology

[Target]

IKKβ:3.59 μM (IC50)

IKKα:8.97 μM (IC50)

[In Vivo]

INH14 (5 µg/g, i.p. for 2 hours) reduces lipopeptide-induced inflammation in mice[1]. Animal Model: 8-week old, male, pathogen-free C57BL/6J mice[1] Dosage: 5 µg/g, one hour before Pam2CSK4 injection Administration: I.P. for 2 hours Result: Decreased TNFα production in mice.

[References]

[1]. Drexel M, et al. INH14, a Small-Molecule Urea Derivative, Inhibits the IKKα/β-Dependent TLR Inflammatory Response. Chembiochem. 2019 Mar 1;20(5):710-717.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₅H₁₆N₂O

[ Molecular Weight ]:
240.30

[ Storage condition ]:
2-8℃

Related Compounds

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