(8S,11R,13S,14S,17S)-11-[4-[(E)-hydroxyiminomethyl]phenyl]-17-methoxy-17-(methoxymethyl)-13-methyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one

Names

[ CAS No. ]:
199396-76-4

[ Name ]:
(8S,11R,13S,14S,17S)-11-[4-[(E)-hydroxyiminomethyl]phenyl]-17-methoxy-17-(methoxymethyl)-13-methyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one

[Synonym ]:
J867
Benzaldehyde,4-((11beta,17beta)-17-methoxy-17-(methoxymethyl)-3-oxoestra-4,9-dien-11-yl)-,1-oxime,(C(E))
Asoprisnil
11beta-(4-((E)-(Hydroxyimino)methyl)phenyl)-17beta-methoxy-17-(methoxymethyl)estra-4,9-dien-3-one
Asoprisnil (USAN/INN)

Biological Activity

[Description]:

Asoprisnil (J867), a selective progesterone receptor modulator, exhibits mixed progesterone agonist and antagonist effects on various progesterone targeted tissues in animal and human[1].

[Related Catalog]:

Signaling Pathways >> Others >> Progesterone Receptor
Research Areas >> Endocrinology

[References]

[1]. Stewart EA, et al. Safety and efficacy of the selective progesterone receptor modulator asoprisnil for heavy menstrual bleeding with uterine fibroids: pooled analysis of two 12-month, placebo-controlled, randomized trials. Hum Reprod. 2019 Apr 1;34(4):623-634.

[2]. Wu XL, et al. Postcoital administration of asoprisnil inhibited embryo implantation and disturbed ultrastructure of endometrium in implantation window in mice. J Huazhong Univ Sci Technolog Med Sci. 2013 Apr;33(2):277-283.

Chemical & Physical Properties

[ Molecular Formula ]:
C28H35NO4

[ Molecular Weight ]:
449.58200

[ Exact Mass ]:
449.25700

[ PSA ]:
68.12000

[ LogP ]:
5.42580

[ Vapour Pressure ]:
0mmHg at 25°C