etiprednol dicloacetate

Names

[ CAS No. ]:
199331-40-3

[ Name ]:
etiprednol dicloacetate

[Synonym ]:
etiprednol dichloroacetate
EDA
BNP-166
(8S,9S,10R,11S,13S,14S,17R)-17-(2,2-Dichloro-acetoxy)-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic acid ethyl ester
etiprednol dichloacetate
ethyl 17α-dichloroacetoxy-11β-hydroxyandrosta-1,4-dien-3-one-17β-carboxylate

Biological Activity

[Description]:

Etiprednol dicloacetate (BNP 166) is an anti-inflammatory agent. Etiprednol dicloacetate inhibits eosinophil accumulation. Etiprednol dicloacetate can be used in the research of inflammatory airway diseases, such as asthma[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[In Vitro]

Etiprednol dicloacetate (1 nM-1 μM) inhibits LPS-induced TNF-α production by human blood[1].

[In Vivo]

Etiprednol dicloacetate (0-100 μg/kg, intranasal inhalation) attenuates peribronchial eosinophilia in the lung of the allergen sensitized and challenged rats[1]. Etiprednol dicloacetate (0.1 μg/kg, intranasal inhalation) inhibits eosinophil accumulation in rats (antigen-induced airway eosinophil infiltration)[3]. Etiprednol dicloacetate (0-20 mg/kg, p.o., 28 days) is well tolerated in rats and dogs[2]. Animal Model: Allergen sensitized and challenged Brown Norway rats[1] Dosage: 0.1, 1, 10, and 100 μg/kg Administration: Intranasal inhalation Result: Decreased the number of eosinophils at the perivascular area of the lung tissue. Decreased the number of mucus secreting cells and antigen-induced formation of perivascular edema.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₃₀Cl₂O₆

[ Molecular Weight ]:
485.39700

[ Exact Mass ]:
484.14200

[ PSA ]:
89.90000

[ LogP ]:
3.91390

Related Compounds

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