MS 023 dihydrochloride

Names

[ CAS No. ]:
1992047-64-9

[ Name ]:
MS 023 dihydrochloride

Biological Activity

[Description]:

MS023 is a potent, selective inhibitor of protein arginine methyltransferases (PRMTs) inhibitor, with IC50s of 30, 119, 83, 4 and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, respectively[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> Histone Methyltransferase

[Target]

IC50: 30 nM (PRMT1), 119 nM (PRMT3), 83 nM (PRMT4), 4 nM (PRMT6), 5 nM (PRMT8)[1]

[References]

[1]. Eram MS, et al. A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases. ACS Chem Biol. 2016 Mar 18;11(3):772-81.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₂₇Cl₂N₃O

[ Molecular Weight ]:
360.32

[ Storage condition ]:
2-8℃

Related Compounds

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