T 98475

Names

[ CAS No. ]:
199119-18-1

[ Name ]:
T 98475

Biological Activity

[Description]:

T-98475 (Compound 26d) is a potent, orally active, non-peptide luteinizing hormone-releasing hormone (LHRH) receptor antagonist with an IC50 of 0.2 nM[1].

[Related Catalog]:

Research Areas >> Endocrinology

Signaling Pathways >> Others >> Others

[Target]

IC50: 0.2 nM (human LHRH receptor), 2 nM (monkey LHRH receptor), 4 nM (monkey anterior pituitaries), 60 nM (rat anterior pituitaries)[1]

[References]

[1]. Imada T, et al. Design, synthesis, and structure-activity relationships of thieno[2,3-b]pyridin-4-one derivatives as a novel class of potent, orally active, non-peptide luteinizing hormone-releasing hormone receptor antagonists. J Med Chem. 2006 Jun 29;49(13):3809-25.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₇H₃₇F₂N₃O₄S

[ Molecular Weight ]:
657.77

[ Exact Mass ]:
657.24700

[ PSA ]:
108.88000

[ LogP ]:
7.92120

Related Compounds

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