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Teduglutide

Names

[ CAS No. ]:
197922-42-2

[ Name ]:
Teduglutide

[Synonym ]:
Revestive
ALX 0600
H-His-Gly-Asp-Gly-Ser-Phe-Ser-Asp-Glu-Met-Asn-Thr-Ile-Leu-Asp-Asn-Leu-Ala-Ala-Arg-Asp-Phe-Ile-Asn-Trp-Leu-Ile-Gln-Thr-Lys-Ile-Thr-Asp-OH
teduglutide
Gattex
Glucagon-like peptide II [2-glycine] (human)

Biological Activity

[Description]:

Teduglutide is a dipeptidyl peptidase IV resistant glucagon-like peptide 2 (GLP-2) analogue. Teduglutide is associated with trophic effects on gut mucosa. Teduglutide can be used for the research of short bowel syndrome (SBS) and Crohn's disease (CD)[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[References]

[1]. Jeppesen PB, et al. Teduglutide (ALX-0600), a dipeptidyl peptidase IV resistant glucagon-like peptide 2 analogue, improves intestinal function in short bowel syndrome patients. Gut. 2005 Sep;54(9):1224-31.

[2]. Buchman AL, et al; Teduglutide Study Group. Teduglutide, a novel mucosally active analog of glucagon-like peptide-2 (GLP-2) for the treatment of moderate to severe Crohn's disease. Inflamm Bowel Dis. 2010 Jun;16(6):962-73.

Chemical & Physical Properties

[ Molecular Formula ]:
C164H252N44O55S

[ Molecular Weight ]:
3752.08000

[ Exact Mass ]:
3749.80000

[ PSA ]:
1649.52000

[ LogP ]:
1.01630

[ Storage condition ]:
-20℃

Related Compounds