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Debutyldronedarone hydrochloride

Names

[ CAS No. ]:
197431-02-0

[ Name ]:
Debutyldronedarone hydrochloride

[Synonym ]:
N-[2-butyl-3-[4-[3-(butylamino)propoxy]benzoyl]-1-benzofuran-5-yl]methanesulfonamide,hydrochloride
Dronedarone Impurity 6

Biological Activity

[Description]:

Debutyldronedarone (SR35021) hydrochloride, the main metabolite of Dronedarone, is a selective thyroid hormone receptor α1 (TRα1) inhibitor. Debutyldronedarone hydrochloride inhibits T3 binding to TRα1 and TRβ1 by 77% and 25%, respectively. Debutyldronedarone hydrochloride can be used for the research of arrhythmic[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Others >> Thyroid Hormone Receptor

[Target]

TRα1/TRβ1[1]


[References]

[1]. Van Beeren HC, et al. Dronerarone acts as a selective inhibitor of 3,5,3'-triiodothyronine binding to thyroid hormone receptor-alpha1: in vitro and in vivo evidence. Endocrinology. 2003 Feb;144(2):552-8.

Chemical & Physical Properties

[ Molecular Formula ]:
C27H37ClN2O5S

[ Molecular Weight ]:
537.11100

[ Exact Mass ]:
536.21100

[ PSA ]:
106.02000

[ LogP ]:
7.88320

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds