8-Oxycoptisine

Names

[ CAS No. ]:
19716-61-1

[ Name ]:
8-Oxycoptisine

[Synonym ]:
6,7-Dihydro-4H-[1,3]dioxolo[4,5-g][1,3]dioxolo[7,8]isoquinolino[3,2-a]isoquinolin-4-one
4H-[1,3]Benzodioxolo[5,6-a]-1,3-benzodioxolo[4,5-g]quinolizin-4-one, 6,7-dihydro-

Biological Activity

[Description]:

8-Oxocoptisine is a natural protoberberine alkaloid with anti-cancer activity[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[In Vitro]

8-Oxocoptisine has cytotoxicity against NCI-N87 (IC50=20.31 μM) and has no cytotoxicity against Caco-2 (IC50>100 μM)[1].

[References]

[1]. Ping Qian, et al. Five new alkaloids from Coptidis Rhizoma-Euodiae Fructus couple and their cytotoxic activities against gastrointestinal cancer cells. Fitoterapia. 2014 Mar;93:74-80.

Chemical & Physical Properties

[ Density]:
1.6±0.0 g/cm3

[ Boiling Point ]:
617.5±0.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₉H₁₃NO₅

[ Molecular Weight ]:
335.310

[ Flash Point ]:
327.3±0.0 °C

[ Exact Mass ]:
335.079010

[ LogP ]:
4.65

[ Vapour Pressure ]:
0.0±0.0 mmHg at 25°C

[ Index of Refraction ]:
1.768

[ Storage condition ]:
2-8℃

Related Compounds

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