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CB-03-01

Names

[ CAS No. ]:
19608-29-8

[ Name ]:
CB-03-01

[Synonym ]:
cortexolone 17α-propionate
[(8R,9S,10R,13S,14S,17R)-17-(2-hydroxyacetyl)-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] propanoate
Pregn-4-ene-3,20-dione, 21-hydroxy-17-(1-oxopropoxy)-
21-Hydroxy-3,20-dioxopregn-4-en-17-yl propionate
CB-03-01
Cortexolone 17 alpha-propionate

Biological Activity

[Description]:

Cortexolone 17 alpha-propionate(CB-03-01) is a new topical and peripherally selective androgen antagonist. IC50 value:Target: Androgen ReceptorCortexolone 17 alpha-propionate (CB-03-01) is a new potent topical antiandrogen potentially useful in acne vulgaris. CB-03-01 1% cream was very well tolerated, and was significantly better than placebo regarding TLC (P = 0·0017), ILC (P = 0·0134) and ASI (P = 0·0090), and also clinically more effective than comparator. The product also induced a faster attainment of 50% improvement in all the above parameters.

[Related Catalog]:

Signaling Pathways >> Others >> Androgen Receptor
Research Areas >> Endocrinology

[References]

[1]. Trifu V, et al. Cortexolone 17α-propionate 1% cream, a new potent antiandrogen for topical treatment of acne vulgaris. A pilot randomized, double-blind comparative study vs. placebo and tretinoin 0·05% cream. Br J Dermatol. 2011 Jul;165(1):177-83.

[2]. Celasco G, et al. Biological profile of cortexolone 17alpha-propionate (CB-03-01), a new topical and peripherally selective androgen antagonist. Arzneimittelforschung. 2004;54(12):881-6.


[Related Small Molecules]

ARN-509 | Dehydroepiandrosterone | Flutamide | ODM-201 | Danazol | 3,3'-Diindolylmethane | AZD3514 | RAD140 | BMS-564929 | GLPG0492 | Cyproterone acetate | LGD-4033 | Lupeol | Andarine | MK-0773

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
538.9±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C24H34O5

[ Molecular Weight ]:
402.524

[ Flash Point ]:
179.3±23.6 °C

[ Exact Mass ]:
402.240631

[ PSA ]:
80.67000

[ LogP ]:
3.76

[ Vapour Pressure ]:
0.0±3.3 mmHg at 25°C

[ Index of Refraction ]:
1.555

Related Compounds