SHP836

Names

[ CAS No. ]:
1957276-35-5

[ Name ]:
SHP836

Biological Activity

[Description]:

SHP836 is a distinct, allosteric site 2 SHP2 inhibitor with IC50 of 12 uM (SHP2 1-525), and selective over the phosphatase domain (SHP2 PTP IC50>100 uM).downregulates DUSP6 mRNA, a downstream MAPK pathway marker, in KYSE-520 cancer cells; enhances pharmacological pathway inhibition in cells combined with SHP099.

[References]

References 1. Fodor M, et al. ACS Chem Biol. 2018 Jan 18. doi: 10.1021/acschembio.7b00980. View Related Products by Target Protein Phosphatase/PTP

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₉Cl₂N₅

[ Molecular Weight ]:
352.263

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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