E3 Ligase Ligand-Linker Conjugates 21

E3 Ligase Ligand-Linker Conjugates 21 is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology.

Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate

Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain

Research Areas >> Cancer

E3 Ligase Ligand-Linker Conjugates 21 is composed of Degron (E3 ubiquitin ligase) and a linker, and they are used in PROTAC technology. E3 Ligase Ligand-Linker Conjugates 21 binds to the targeting ligand to induce the target protein (including BRD4, BRD2, and BRD3) degradation[1].

[1]. Methods to induce targeted protein degradation through bifunctional molecules. WO 2017007612 A1

(+)-JQ1 | GSK126 | Tazemetostat (EPZ-6438) | Birabresib (OTX015) | A 485 | Curcumin | ARV-771 | ARV-825 | I-BET762 | BI 2536 | GSK343 | C646 | 3-Deazaneplanocin A (hydrochloride) | I-BET151 | 666-15