Thalidomide-NH-(CH2)2-NH2 TFA

Names

[ CAS No. ]:
1957235-67-4

[ Name ]:
Thalidomide-NH-(CH2)2-NH2 TFA

Biological Activity

[Description]:

Thalidomide-NH-(CH2)2-NH2 TFA is an alkyl-modified Thalidomide (HY-14658) that acts as a Cereblon ligand to recruit CRBN proteins. Thalidomide-NH-(CH2)2-NH2 TFA is a key intermediate in the synthesis of CRBN-based PROTAC molecules designed to synthesize small PROTAC molecules targeting SHP2 protein.

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> Ligand for E3 Ligase

Chemical & Physical Properties

[ Melting Point ]:
>224°C (dec.)

[ Molecular Formula ]:
C₁₇H₁₇F₃N₄O₆

[ Molecular Weight ]:
430.34

[ Appearance of Characters ]:
Solid | Light Orange to Yellow

[ Storage condition ]:
Hygroscopic, Refrigerator, under inert atmosphere

[ Water Solubility ]:
DMSO (Slightly), Methanol (Slightly)

Related Compounds

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