Thalidomide-NH-(CH2)2-NH-Boc

Names

[ CAS No. ]:
1957235-57-2

[ Name ]:
Thalidomide-NH-(CH2)2-NH-Boc

Biological Activity

[Description]:

Thalidomide-NH-(CH2)2-NH-Boc is a Boc-modified Thalidomide (HY-14658) that acts as a Cereblon ligand to recruit CRBN protein. The Boc protecting group at the end of Thalidomide-NH-(CH2)2-NH-Boc can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-NH-(CH2)2-NH-Boc is a key intermediate in the synthesis of CRBN-based PROTAC molecules.

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> Ligand for E3 Ligase

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₂₄N₄O₆

[ Molecular Weight ]:
416.43

[ Appearance of Characters ]:
Solid | Yellow

[ Water Solubility ]:
Dichloromethane, Ethyl Acetate, Methanol

Related Compounds

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