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SJ-3366

Names

[ CAS No. ]:
195720-26-4

[ Name ]:
SJ-3366

[Synonym ]:
IQP0410
Nab 2F5
Nab 2G12
SJ-3366

Biological Activity

[Description]:

SJ-3366 (IQP-0410) is a potent inhibitor of HIV nonnucleoside reverse transcriptase[1]. SJ-3366 (IQP-0410) inhibits HIV at sub-nanomolar concentrations primarily through a typical non-nucleoside mechanism[2].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV
Research Areas >> Inflammation/Immunology

[Target]

nonnucleoside reverse transcriptase[1]


[References]

[1]. Ham AS, Lustig W, Yang L, Boczar A, Buckheit KW, Buckheit RW Jr. In vitro and ex vivo evaluations on transdermal delivery of the HIV inhibitor IQP-0410. PLoS One. 2013;8(9):e75306.

[2]. Buckheit RW Jr, Watson Buckheit K, Sturdevant CB, Buckheit RW 3rd. Selection and characterization of viruses resistant to the dual acting pyrimidinedione entry and non-nucleoside reverse transcriptase inhibitor IQP-0410. Antiviral Res. 2013;100(2):382-391.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H24N2O3

[ Molecular Weight ]:
352.42700

[ Exact Mass ]:
352.17900

[ PSA ]:
72.19000

[ LogP ]:
3.32530

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds