Z-Val-Phe-OH

Names

[ CAS No. ]:
19542-51-9

[ Name ]:
Z-Val-Phe-OH

[Synonym ]:
N-Cbz-L-Val-L-Phe
Z-L-VALYL-L-PHENYLALANINE
N-CBZ-VAL-PHE
z-val-phe
N-carbobenzyloxy-Val-Phe
N-benzyloxycarbonyl-valyl-phenylalanine methyl ester
Cbz-Val-Phe-OH
N-BENZYLOXYCARBONYL-L-VALYL-L-PHENYLALANINE

Chemical & Physical Properties

[ Density]:
1.211 g/cm3

[ Boiling Point ]:
648.6ºC at 760 mmHg

[ Molecular Formula ]:
C₂₂H₂₆N₂O₅

[ Molecular Weight ]:
398.45200

[ Flash Point ]:
346.1ºC

[ Exact Mass ]:
398.18400

[ PSA ]:
104.73000

[ LogP ]:
3.53130

[ Vapour Pressure ]:
1.04E-17mmHg at 25°C

[ Index of Refraction ]:
1.569

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Inhibition of calpain is a component of nitric oxide-induced down-regulation of human mast cell adhesion.

J. Immunol. 170(1) , 287-93, (2003)

Nitric oxide is an important messenger that regulates mast cell activity by modifications to gene expression and intracellular pathways associated with exocytosis and adhesion. Integrin interactions w...

Calpain mediates ischemic injury of the liver through modulation of apoptosis and necrosis.

Gastroenterology 116(1) , 168-78, (1999)

Calpain proteases have been implicated in cell death by necrosis and more recently by apoptosis. Experiments were designed to determine the role of calpain proteases in ischemic rat liver injury by me...

Calpain inhibition prevents sinusoidal endothelial cell apoptosis in the cold ischemic rat liver.

Transplantation 68(1) , 136-40, (1999)

Cold preservation of the liver followed by reperfusion results in sinusoidal endothelial cell (SEC) apoptosis. Calpain-like activity is dramatically increased during reperfusion and inhibition of calp...