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Fmoc-N-PEG20-acid

Names

[ CAS No. ]:
1952360-93-8

[ Name ]:
Fmoc-N-PEG20-acid

[Synonym ]:
MFCD21363316
2,7,10,13,16,19,22,25,28,31,34,37,40,43,46,49,52,55,58,61,64-Heneicosaoxa-4-azaheptahexacontan-67-oic acid, 1-(9H-fluoren-9-yl)-3-oxo-
1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16,19,22,25,28,31,34,37,40,43,46,49,52,55,58,61,64-henicosaoxa-4-azaheptahexacontan-67-oic acid

Biological Activity

[Description]:

Fmoc-N-amido-PEG20-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
1033.9±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C58H97NO24

[ Molecular Weight ]:
1192.383

[ Flash Point ]:
579.1±34.3 °C

[ Exact Mass ]:
1191.640015

[ LogP ]:
-3.43

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.502

Related Compounds