Vepalimomab

Names

[ CAS No. ]:
195158-85-1

[ Name ]:
Vepalimomab

Biological Activity

[Description]:

Vepalimomab (Anti-Human AOC3 Recombinant Antibody) is a monoclonal antibody that blocks vascular adhesion protein 1 (VAP-1). Vepalimomab has anti-inflammatory effects[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[In Vivo]

Vepalimomab (Anti-human-VAP-1 mAb 1B2; 3 mg/kg; i.v; once) 显示在发炎的皮肤和滑膜中上调[2]。 Vepalimomab (3 mg/kg; i.v) 显示初始快速分布相在猪体内的半衰期为 26 分钟，相应的消除相半衰期为 431 分钟[2]。

[References]

[1]. Petri J Vainio, et al. Safety of blocking vascular adhesion protein-1 in patients with contact dermatitis. Basic Clin Pharmacol Toxicol. 2005 Jun;96(6):429-35.

[2]. K Jaakkola, et al. In vivo detection of vascular adhesion protein-1 in experimental inflammation. Am J Pathol. 2000 Aug;157(2):463-71.

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds

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