BKI-1369

Names

[ CAS No. ]:
1951431-22-3

[ Name ]:
BKI-1369

Biological Activity

[Description]:

BKI-1369 is a bumped kinase inhibitor (BKI). BKI-1369 increases human Ether-a-go-go-related gene (hERG)-inhibitory activity with an IC50 of 1.52 μM. BKI-1369 reduces the parasite burden and diseases severity in the gnotobiotic pig model. BKI-1369 has been well characterized for potency, stability, metabolism, toxicity, pharmacokinetics and is potent against C. parvum in infected mice and calves[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Parasite

Research Areas >> Infection

[Target]

IC50: 1.52 μM (hERG)[1]

[References]

[1]. Lee S, et al. Therapeutic Efficacy of Bumped Kinase Inhibitor 1369 in a Pig Model of Acute Diarrhea Caused by Cryptosporidium hominis. Antimicrob Agents Chemother. 2018 Jun 26;62(7).

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₂₇N₇O

[ Molecular Weight ]:
417.51

BKI-1369

Names

Biological Activity

Chemical & Physical Properties

Related Compounds