Thalidomide-O-amido-C6-NH2

Names

[ CAS No. ]:
1950635-13-8

[ Name ]:
Thalidomide-O-amido-C6-NH2

Biological Activity

[Description]:

Thalidomide-O-amido-C6-NH2 (Cereblon Ligand-Linker Conjugates 11), a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate

[Target]

Cereblon

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Bradner J, et al. Targeted protein degradation to attenuate adoptive t-cell therapy associated adverse inflammatory responses. WO 2017024318 A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₂₆N₄O₆

[ Molecular Weight ]:
430.45

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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