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Apoptolidin

Names

[ CAS No. ]:
194874-06-1

[ Name ]:
Apoptolidin

[Synonym ]:
Apoptolidin A Ready Made
2-Amino-1-hydroxy-7-methoxynitosene
Apo-mitomycin A

Biological Activity

[Description]:

Apoptolidin is a polyketide isolated from Nocardiopsis bacteria[1]. Apoptolidin is a selective mitochondrial F1FO ATPase inhibitor. Apoptolidin is an apoptosis inducer and induces apoptotic cell death in cells transformed with the adenovirus type 12 oncogenes including ElA (IC50=10-17 ng/ml) but not in normal cells[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> Membrane Transporter/Ion Channel >> ATP Synthase

[In Vitro]

Apoptolidin has cytotoxicity against normal and transformed cells, it against RG-E1A-7,RG-E1A19K-2, RG-E1A54K-9, RG-E1-4 and Adl2-3Y1 with IC50 values of 11 ng/ml,10 ng/ml,13 ng/ml, 10 ng/ml and 17 ng/ml, respectively[1].

[References]

[1]. J W Kim, et al. Apoptolidin, a new apoptosis inducer in transformed cells from Nocardiopsis sp. J Antibiot (Tokyo). 1997 Jul;50(7):628-30.

[2]. A R Salomon, et al. Understanding and exploiting the mechanistic basis for selectivity of polyketide inhibitors of F(0)F(1)-ATPase. Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14766-71.

Chemical & Physical Properties

[ Molecular Formula ]:
C58H96O21

[ Molecular Weight ]:
1129.37000

[ Exact Mass ]:
1128.64000

[ PSA ]:
289.67000

[ LogP ]:
3.58730

MSDS

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Safety Information

[ RIDADR ]:
NA 1993 / PGIII

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds