Taurolidine

Names

[ CAS No. ]:
19388-87-5

[ Name ]:
Taurolidine

[Synonym ]:
4,4'-Methylenebis(tetrahydro-1,2,4-thiadiazine) 1,1,1',1'-tetraoxide
4,4'-methanediylbis(1,2,4-thiadiazinane) 1,1,1',1'-tetraoxide
2H-1,2,4-Thiadiazine, 4,4'-methylenebis[tetrahydro-, 1,1,1',1'-tetraoxide
4,4'-Methylenebis(tetrahydro-1,2,4-sulfadiazine 1,1-dioxide)
4,4'-Methylenebis(perhydro-1,2,4-thiadiazine 1,1-dioxide)
Bis(1,1-dioxoperhydro-1,2,4-thiadiazin-4-yl)methane
4,4'-Methylenebis(1,2,4-thiadiazinane) 1,1,1',1'-tetraoxide
Taurolin
Taurolidine
Tauroline

Biological Activity

[Description]:

Taurolidine is a broad-spectrum antimicrobial for the prevention of central venous catheter-related infections. Taurolidine has a direct and selective antineoplastic effect on brain tumor cells by the induction of apoptosis[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Haro C, et al. Taurolidine, an antiseptic for the prevention of central venous catheter-related infections. Rev Chilena Infectol. 2019 Aug;36(4):414-420.

[2]. Stendel R, et al. Treatment of glioblastoma with intravenous taurolidine. First clinical experience. Anticancer Res. 2004 Mar-Apr;24(2C):1143-7.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
471.2±55.0 °C at 760 mmHg

[ Melting Point ]:
156ºC

[ Molecular Formula ]:
C₇H₁₆N₄O₄S₂

[ Molecular Weight ]:
284.356

[ Flash Point ]:
238.8±31.5 °C

[ Exact Mass ]:
284.061310

[ PSA ]:
115.58000

[ LogP ]:
-2.55

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.564

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Taurolidine induces epithelial-mesenchymal transition via up-regulation of the transcription factor Snail in human pancreatic cancer cell lines.

Int. J. Colorectal Dis. 29(11) , 1339-48, (2014)

The taurine derivative taurolidine (TRD) exerts anti-neoplastic effects in a variety of tumor models. On the other hand, TRD at low doses was shown to reduce cell-cell adhesion, a prerequisite for met...

Central venous catheters and catheter locks in children with cancer: a prospective randomized trial of taurolidine versus heparin.

Pediatr. Blood Cancer 60(8) , 1292-8, (2013)

To determine if the catheter lock taurolidine can reduce the number of catheter-related bloodstream infections (CRBSI) in pediatric cancer patients with tunneled central venous catheters (CVC).During ...

Taurolidine specifically inhibits growth of neuroblastoma cell lines in vitro.

J. Pediatr. Hematol. Oncol. 36(4) , e219-23, (2014)

Neuroblastoma is a common pediatric solid tumor with poor outcome for metastatic disease. Thus, novel therapeutic options are of main interest. The anti-neoplastic properties of taurolidine have been ...

Related Compounds

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