Commendamide

Names

[ CAS No. ]:
193825-78-4

[ Name ]:
Commendamide

[Synonym ]:
N-(3-hydroxy-1-oxohexadecyl)-glycine
N-(3-Hydroxyhexadecanoyl)glycine
Commendamide
Glycine, N-(3-hydroxy-1-oxohexadecyl)-

Biological Activity

[Description]:

Commendamide is a GPCR G2A/GPR132 agonist (EC50: 11.8 μM). Commendamide can be used for research of autoimmunity and atherosclerosis[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[Target]

EC50: 11.8 μM (GPR132)[1]

[References]

[1]. Cohen LJ, et al. Functional metagenomic discovery of bacterial effectors in the human microbiome and isolation of commendamide, a GPCR G2A/132 agonist. Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):E4825-34.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
532.5±35.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₈H₃₅NO₄

[ Molecular Weight ]:
329.47

[ Flash Point ]:
275.9±25.9 °C

[ Exact Mass ]:
329.256622

[ LogP ]:
4.36

[ Vapour Pressure ]:
0.0±3.2 mmHg at 25°C

[ Index of Refraction ]:
1.480

Related Compounds

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