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alamifovir

Names

[ CAS No. ]:
193681-12-8

[ Name ]:
alamifovir

[Synonym ]:
mcc 478

Biological Activity

[Description]:

Alamifovir (LY582563; MCC-478), a purine nucleotide analogue prodrug, shows potent activity against wild type and lamivudine resistant hepatitis B virus (HBV). Alamifovir has high activity against HBV replication and sustained antiviral effect[1][2].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> HBV

[In Vitro]

MCC-478 (0-10 μM) 对野生型 HBV 的 EC50 为 0.027 μM，对 M552I 为 2.6 μM，对 M552V 为 3.3 μM，对 L528M/M552V 为 2.0 μM[ 1]。

[References]

[1]. Suzane Kioko Ono-Nita, et al. Novel nucleoside analogue MCC-478 (LY582563) is effective against wild-type or lamivudine-resistant hepatitis B virus. Antimicrob Agents Chemother. 2002 Aug;46(8):2602-5.  

[2]. Danny K W Soon, et al. Safety and efficacy of alamifovir in patients with chronic hepatitis B virus infection. J Hepatol. 2004 Nov;41(5):852-8.  

Chemical & Physical Properties

[ Density]:
1.61g/cm3

[ Boiling Point ]:
635.9ºC at 760mmHg

[ Molecular Formula ]:
C19H20F6N5O5PS

[ Molecular Weight ]:
575.42200

[ Flash Point ]:
338.4ºC

[ Exact Mass ]:
575.08300

[ PSA ]:
158.72000

[ LogP ]:
5.47450

[ Vapour Pressure ]:
4.51E-16mmHg at 25°C

[ Index of Refraction ]:
1.582

Synthetic Route

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