PC945

PC945 is a novel broad spectrum antifungal agent that potently inhibits Aspergillus fumigatus sterol 14α-demethylase (CYP51A and CYP51B) with IC50 of 0.23 and 0.22 uM, respectively; shows MIC values 0.032 to >8 ug/ml against 96 clinically isolated A. fumigatus strains, demonstrates activity against itraconazole-susceptible and -resistant A. fumigatus growth with IC50 of 0.0012 to 0.034 ug/ml; PC945 is a broad spectrum of pathogenic fungi with MIC 0.0078 to 2 ug/ml, and exhibits activity in vivo. Fungal Infection Phase 1 Clinical

References 1. Colley T, et al. Antimicrob Agents Chemother. 2017 Apr 24;61(5). pii: e02280-16. 2. Kimura G, et al. Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e00124-17. View Related Products by Target Fungal Fungal Infection