CDC801

CDC801 is a potent and orally active phosphodiesterase 4 (PDE4) and tumor necrosis factor-α (TNF-α) inhibitor with IC50 of 1.1 μM and 2.5 μM, respectively.

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)

Signaling Pathways >> Apoptosis >> TNF Receptor

Research Areas >> Cancer

IC50: 1.1μM (PDE4), 2.5μM (TNF-α)[1]

The more detailed information refer to the Compound 6b in the reference 1 (PMID:19256507)[1].

[1]. Man HW, et al. Discovery of (S)-N-[2-[1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl] acetamide (apremilast), a potent and orally active phosphodiesterase 4and tumor necrosis factor-alpha inhibitor. J Med Chem. 2009 Mar 26;52(6):1522-4.

3-Isobutyl-1-methylxanthine | AP 1903 | Pomalidomide | rolipram | Shikonine | PF-04957325 | AN-2728 | QNZ (EVP4593) | GLPG1690 | BAY-60-7550 | TIC10 | Icariin | Fisetin | Ibudilast | PF-8380