Tumor Targeted Pro-Apoptotic Peptide trifluoroacetate salt

Tumor targeted pro-apoptotic peptide (CNGRC-GG-D(KLAKLAK)2) is an anti-tumor peptide. Tumor targeted pro-apoptotic peptide disrupts mitochondrial membranes and promotes apoptosis, showing anticancer activity in mice[1].

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Tumor targeted pro-apoptotic peptide (10 µM; 0-20 min) induces mitochondrial swelling in DMECs[1]. Tumor targeted pro-apoptotic peptide (100 µM; 72 h) induces apoptosis in DMECs[1]. Cell Viability Assay[1] Cell Line: DMECs Concentration: 10 µM Incubation Time: 0-20 min Result: Induced considerable mitochondrial swelling at a concentration of 10 µM, and mild swelling was evident even at 3 µM. Apoptosis Analysis[1] Cell Line: DMECs Concentration: 100 µM Incubation Time: 72 h Result: Showed the classic morphological indicators of apoptosis, including nuclear condensation and fragmentation.

Tumor targeted pro-apoptotic peptide inhibits both primary tumor growth and metastasis in mice[1]. Animal Model: Tumor targeted pro-apoptotic peptide (250 µg/mice; tail vein injection; 250 µg a week for 17 weeks) inhibits both primary tumor growth and metastasis in mice[1]. Dosage: 250 µg/mice Administration: Tail vein injection; 250 µg a week for 17 weeks Result: Exhibited antitumor activity in vivo.