SA 16
Names
[ CAS No. ]:
1919884-11-9
[ Name ]:
SA 16
Biological Activity
[Description]:
A potent, dual PDK1 and Aurora kinase A inhibitor with IC50 of 416 and 35 nM, respectively; blocks glioblastoma multiforme (GBM) proliferation with no toxicity in normal cells, induces GBM apoptosis and inhibits cell migration; exhibits an increased efficacy against glioma stem cells (GSCs), inducing their differentiation and apoptosis.
[References]
References 1. Daniele S, et al. ACS Chem Neurosci. 2017 Jan 18;8(1):100-114. 2. Nagashima K, et al. J Biol Chem. 2011 Feb 25;286(8):6433-48. View Related Products by Target Aurora Kinase
Chemical & Physical Properties
[ Molecular Formula ]:
C33H24F2N6O4
[ Molecular Weight ]:
606.59
Related Compounds
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