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Epieriocalyxin A

Names

[ CAS No. ]:
191545-24-1

[ Name ]:
Epieriocalyxin A

[Synonym ]:
(1S,1'S,2R,6'S,9'R,10'R)-3,3,10'-Trimethyl-2',6,11'-trioxo-3'-oxaspiro[cyclohexane-1,5'-tricyclo[7.2.1.0]dodecane]-4-ene-2-carbaldehyde

Biological Activity

[Description]:

epi-Eriocalyxin A (Epieriocalyxin A), a diterpenoid isolated from Isodon eriocalyx, induces colon cancer apoptosis. epi-Eriocalyxin A also inhibits ERK1/2 and JNK activation, which suppresses Bcl-2 expression[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> MAPK/ERK Pathway >> ERK
Signaling Pathways >> MAPK/ERK Pathway >> JNK
Signaling Pathways >> Stem Cell/Wnt >> ERK

[References]

[1]. Zhou Wang, et al. Epieriocalyxin A Induces Cell Apoptosis Through JNK and ERK1/2 Signaling Pathways in Colon Cancer Cells. Cell Biochem Biophys. 2015 Nov;73(2):559-564.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
563.4±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C20H24O5

[ Molecular Weight ]:
344.402

[ Flash Point ]:
248.4±30.2 °C

[ Exact Mass ]:
344.162384

[ PSA ]:
77.51000

[ LogP ]:
1.69

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.563

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds