Ophiobolin C

Names

[ CAS No. ]:
19022-51-6

[ Name ]:
Ophiobolin C

[Synonym ]:
3-Hydroxy-5-oxoophiobola-7,19-dien-25-al
Ophiobolin C-Triol

Biological Activity

[Description]:

Ophiobolin C inhibits CCR5 binding to the envelop protein gp120 and CD4, which is responsible for mediating the entry of HIV-1 into cells[1]. Ophiobolin C is also cytotoxic to chronic lymphocytic leukemia cells[2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> CCR

Signaling Pathways >> Anti-infection >> HIV

Research Areas >> Infection

Signaling Pathways >> Immunology/Inflammation >> CCR

[References]

[1]. Jayasuriya H, et al. Isolation and structure of antagonists of chemokine receptor (CCR5). J Nat Prod. 2004 Jun;67(6):1036-8.

[2]. Bladt TT, et al. Bio-activity and dereplication-based discovery of ophiobolins and other fungal secondary metabolites targeting leukemia cells. Molecules. 2013 Nov 26;18(12):14629-50.

Chemical & Physical Properties

[ Density]:
1.064g/cm3

[ Boiling Point ]:
512.4ºC at 760mmHg

[ Molecular Formula ]:
C₂₅H₃₈O₃

[ Molecular Weight ]:
386.57

[ Flash Point ]:
277.8ºC

[ Exact Mass ]:
386.28200

[ PSA ]:
54.37000

[ LogP ]:
5.27670

[ Vapour Pressure ]:
1.21E-12mmHg at 25°C

[ Index of Refraction ]:
1.544

Related Compounds

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