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SLM 6031434 hydrochloride

Names

[ CAS No. ]:
1897379-34-8

[ Name ]:
SLM 6031434 hydrochloride

[Synonym ]:
SLM6031434 (hydrochloride)
(2S)-2-{3-[4-(Octyloxy)-3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl}-1-pyrrolidinecarboximidamide hydrochloride (1:1)
1-Pyrrolidinecarboximidamide, 2-[3-[4-(octyloxy)-3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl]-, (2S)-, hydrochloride (1:1)

Biological Activity

[Description]:

SLM6031434 hydrochloride is a highly selective sphingosine kinase 2 (SphK2) inhibitor with Kis of 0.4 μM, 0.5 μM, >20 μM, 22 μM for mSphK2, rSphK2, mSphK1 and rSphK1, respectively. SLM6031434 hydrochloride decrease Sphingosine 1-phosphate (S1P) levels in U937 monocytic leukemia cells. SLM6031434 hydrochloride has the potential for renal fibrosis research[1][2].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Immunology/Inflammation >> SPHK

[References]

[1]. Yugesh Kharel, et al. Sphingosine Kinase 2 Inhibition and Blood Sphingosine 1-Phosphate Levels. J Pharmacol Exp Ther. 2015 Oct;355(1):23-31.

Chemical & Physical Properties

[ Molecular Formula ]:
C22H31ClF3N5O2

[ Molecular Weight ]:
489.96

[ Exact Mass ]:
489.211853

Related Compounds