Chlorothalonil

Names

[ Name ]:
Chlorothalonil

[Synonym ]:
meta-TCPN
2,4,5,6-Tetrachloroisophthalonitrile
Chloroalonil
MFCD00045594
2,4-Dicyanotetrachlorobenzene
1,3-dicyano-2,4,5,6-tetrachlorobenzene
2,4,5,6-tetrachlorobenzene-1,3-dicarbonitrile
2,4,5,6-tetrachloro-1,3-benzenedicarbonitrile
m-Tcpn
2,4,5,6-tetrachloro-1,3-dicyanobenzene
Nopcocide
TPN
Perchloroisophthalonitrile
2,4,5,6-tetrachloroisophthalodinitrile
Chlorothalonil
EINECS 217-588-1
tetrachloroisophthalonitrile
Bravo
Daconil
1,3-Benzenedicarbonitrile, 2,4,5,6-tetrachloro-
Tetrachloroisophthalodinitrile
1,3-dicyanotetrachlorobenzene

Biological Activity

[Description]:

Chlorothalonil is a broad spectrum fungicide and is effective in protecting plants against fungal diseases caused mainly by Phytophthora infestans and Alternaria solani. Chlorothalonil is used for controlling of fungal foliar diseases of vegetables and crops[1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

[References]

[1]. Pengfei Zhang, et al. Low Dose Chlorothalonil Impairs Mouse Spermatogenesis Through the Intertwining of Estrogen Receptor Pathways With Histone and DNA Methylation.Chemosphere. 2019 Sep;230:384-395.

[2]. Małgorzata Baćmaga, et al. The Influence of Chlorothalonil on the Activity of Soil Microorganisms and Enzymes. Ecotoxicology. 2018 Nov;27(9):1188-1202.

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
350.5±37.0 °C at 760 mmHg

[ Melting Point ]:
250-251ºC

[ Molecular Formula ]:
C₈Cl₄N₂

[ Molecular Weight ]:
265.911

[ Flash Point ]:
153.8±20.7 °C

[ Exact Mass ]:
263.881561

[ PSA ]:
47.58000

[ LogP ]:
2.88

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.633

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NT2600000

CHEMICAL NAME :: Isophthalonitrile, tetrachloro-

CAS REGISTRY NUMBER :: 1897-45-6

LAST UPDATED :: 199710

DATA ITEMS CITED :: 28

MOLECULAR FORMULA :: C8-Cl4-N2

MOLECULAR WEIGHT :: 265.90

WISWESSER LINE NOTATION :: NCR BG CG DG FG ECN

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 310 mg/m3/1H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2500 ug/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle contraction or spasticity

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6750 mg/kg/90D-C

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - changes in bladder weight

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 142 gm/kg/80W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors

MUTATION DATA

TEST SYSTEM :: Fish - not otherwise specified

DOSE/DURATION :: 1400 ppt/7D (Continuous)

REFERENCE :: HYHPDO Hunan Yixueyuan Xuebao. Journal of Hunan Medical College. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) Beginning history not known. Volume(issue)/page/year: 12,153,1987 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 30,319,1983 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 30,319,1983 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - T1833 No. of Facilities: 3268 (estimated) No. of Industries: 21 No. of Occupations: 26 No. of Employees: 62724 (estimated) No. of Female Employees: 6716 (estimated)

Safety Information

[ Symbol ]:

GHS05, GHS06, GHS08, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H317-H318-H330-H335-H351-H410

[ Precautionary Statements ]:
P260-P273-P280-P284-P304 + P340 + P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
T+;N

[ Risk Phrases ]:
R26;R37;R40;R41;R43;R50/53

[ Safety Phrases ]:
S28-S36/37/39-S45-S60-S61-S36/37-S26

[ RIDADR ]:
3276

[ RTECS ]:
NT2600000

[ Packaging Group ]:
I

[ Hazard Class ]:
6.1(a)

[ HS Code ]:
2926909090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2926909038

[ Summary ]:
HS: 2926909038 fenoxanil Educational tariff:17.0% Tax rebate rate:9.0% Regulatory conditions:S(Registration certificate of import and export) Lowest tariff:6.5% General tariff:30.0%

Articles

Effects of seven antifouling compounds on photosynthesis and inorganic carbon use in sugar kelp Saccharina latissima (Linnaeus).

Arch. Environ. Contam. Toxicol. 63(3) , 365-77, (2012)

Macroalgae depend on carbon-concentrating mechanisms (CCMs) to maintain a high photosynthetic activity under conditions of low carbon dioxide (CO(2)) availability. Because such conditions are prevalen...

Development and validation of one-step ultrasound-assisted extraction for simultaneous determination of multiclass fungicides in soils.

J. AOAC Int. 98(1) , 192-200, (2015)

A rapid, efficient, and simple one-step ultrasound-assisted extraction (UAE) method was developed for the analysis of seven fungicides (cymoxanil, metalaxyl, mandipropamid, folpet, chlorothalonil, kre...

Photoreduction of chlorothalonil fungicide on plant leaf models.

Environ. Sci. Technol. 45(22) , 9582-9, (2011)

Photodegradation is seldom considered at the surface of vegetation after crop spraying. Chlorothalonil, a broad-spectrum foliar fungicide with a very widespread use worldwide, was considered. To repre...