t-Boc-N-amido-PEG3-thiol

Names

[ Name ]:
t-Boc-N-amido-PEG3-thiol

[Synonym ]:
2-Methyl-2-propanyl (2-{2-[2-(2-sulfanylethoxy)ethoxy]ethoxy}ethyl)carbamate
MFCD29764342
Carbamic acid, N-[2-[2-[2-(2-mercaptoethoxy)ethoxy]ethoxy]ethyl]-, 1,1-dimethylethyl ester

Biological Activity

[Description]:

Thiol-PEG3-NHBoc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1014.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
419.4±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₃H₂₇NO₅S

[ Molecular Weight ]:
309.422

[ Flash Point ]:
207.5±27.3 °C

[ Exact Mass ]:
309.160980

[ LogP ]:
1.10

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.472

Related Compounds

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